Why the study?
What is the long-term risk of adverse events in patients with unprovoked versus provoked acute pulmonary embolism?
What is the long-term risk of adverse events in patients with unprovoked versus provoked acute pulmonary embolism?
Acute pulmonary embolism is associated with high rates of serious adverse events, occurring in half of patients within 4 years, with differing risk profiles between unprovoked and provoked PE.
Supports tailored long-term surveillance by PE trigger; leaves open whether unprovoked cases warrant dedicated RCTs for extended therapy.
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Klok et al. (2009) studied this question.
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