What question did this study set out to answer?

To investigate associations between cardiac troponin T, endothelin-1, and cardiac disease in dialysis patients.

August 1, 1999Nephrology Dialysis TransplantationOpen Access

Increased cardiac troponin T and endothelin-1 concentrations in dialysis patients may indicate heart disease

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Population

62 dialysis patients (36 haemodialysis, 26 peritoneal dialysis) without symptoms of acute myocardial ischaemia

Design

Cross-sectional

Authors

CLChristian LöwbeerKarolinska Institutet AOA. Ottosson-SeebergerKarolinska Institutet SGSven A. GustafssonKarolinska Institutet

Discussion

Member takes

Implication

Elevated cTnT may signal underlying IHD or LVH in stable dialysis patients; hypothesis-generating and should not yet change practice.

Key Points

To investigate associations between cardiac troponin T, endothelin-1, and cardiac disease in dialysis patients.
Analyzed serum concentrations of cTnT, TnI, CKMB, and CK in 36 HD and 26 PD patients without acute myocardial ischaemia.
Measured plasma ET-1 and big ET-1 in HD patients and LVMI in 27 HD patients.
Compared results between patients with and without ischaemic heart disease (IHD).
Elevated cTnT found in 20 of 36 HD and 8 of 26 PD patients; cTnI elevated in 4 of 62 dialysis patients.
HD+PD patients with IHD had significantly higher cTnT and ET-1 levels than those without IHD.
Positive correlation noted between cTnT and both big ET-1 and left ventricular mass index in HD patients.

Structured PICO

Population

62 dialysis patients (36 haemodialysis, 26 peritoneal dialysis) without symptoms of acute myocardial ischaemia

Outcome

Associations between cTnT, big ET-1, ET-1, other cardiac markers and cardiac disease (ischaemic heart disease and left ventricular hypertrophy)surrogate

Elevated circulating cTnT in dialysis patients without acute ischemia may reflect underlying left ventricular hypertrophy or ischemic heart disease, potentially associated with ET-1 and big ET-1 levels.

Cite This Study

Löwbeer et al. (1999) studied this question.

synapsesocial.com/papers/6a702b3826a7f98052dcada7 https://doi.org/10.1093/ndt/14.8.1948

Topics

Women and heart disease

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Increased cardiac troponin T and endothelin-1 concentrations in dialysis patients may indicate heart disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Increased cardiac troponin T and endothelin-1 concentrations in dialysis patients may indicate heart disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider