Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2013Journal of Investigative Medicine

Inhibition of Renin-Angiotensin System: Implications for Diabetes Control and Prevention

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do inhibitors of the renin-angiotensin system reduce new-onset diabetes in patients with insulin resistance?

Population

Patients with insulin resistance such as primary hypertension, and experimental models of insulin resistance

Design

Review

Authors

SPSharma PrabhakarTexas Tech University

Discussion

Loading...

Member takes

Overview

Supports potential diabetes prevention with RAS inhibitors in insulin resistance; leaves open need for randomized confirmation.

Structured PICO

Do inhibitors of the renin-angiotensin system reduce new-onset diabetes in patients with insulin resistance?

P
Population
Patients with insulin resistance such as primary hypertension, and experimental models of insulin resistance (e.g., ZSF rat and other animal models)
I
Intervention
Inhibitors of renin-angiotensin system (angiotensin-converting enzyme inhibitors and angiotensin receptor blockers)
O
Outcome
New-onset diabeteshard clinical

Inhibitors of the renin-angiotensin system are associated with a significant reduction in new-onset diabetes in patients with insulin resistance, supported by cross-talk between angiotensin and insulin signaling pathways.

Cite This Study

Sharma Prabhakar (2013) studied this question.

synapsesocial.com/papers/6a702b3f2163a0a01bc462fchttps://doi.org/10.2310/jim.0b013e31828298ce
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Crosstalk Between Insulin and Renin-Angiotensin-Aldosterone Signaling Systems and its Effect on Glucose Metabolism and Diabetes Prevention2008 · 89 citations
  2. 2Link between the renin–angiotensin system and insulin resistance: Implications for cardiovascular disease2012 · 218 citations
  3. 3The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome2012 · 279 citations
  4. 4Mechanisms of Reactive Oxygen Species–Dependent Downregulation of Insulin Receptor Substrate-1 by Angiotensin II2005 · 112 citations
  5. 5Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial2006 · 163 citations