May 11, 2007AJP Heart and Circulatory Physiology

Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors

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Population

Rat heart in vivo

Comparison

Angiotensin-(1-7) administration vs Angiotensin II alone, insulin alone, or…

Design

Preclinical

Authors

JGJorge F. GianiCedars-Sinai Medical Center MGMariela M. GironacciUniversity of Buenos Aires MMMarina C. MuñozInstituto de Química y Fisicoquímica Biológicas

Discussion

Member takes

Implication

May inform ANG II-insulin crosstalk mechanisms; leaves open therapeutic relevance in hypertension or insulin resistance.

Structured PICO

Population

Rat heart in vivo

Intervention

Angiotensin-(1-7) administration

Comparator

Angiotensin II alone, insulin alone, or co-administration with inhibitors (losartan, A-779, wortmannin, AG-490)

Outcome

Phosphorylation of Janus kinase 2 (JAK2), insulin receptor substrate (IRS)-1, and Aktsurrogate

ANG-(1-7) counteracts the inhibitory effects of ANG II on insulin signaling in the heart, suggesting a protective physiological role against insulin resistance and cardiovascular disease.

Cite This Study

Giani et al. (2007) studied this question.

synapsesocial.com/papers/6a702b3f2163a0a01bc46304 https://doi.org/10.1152/ajpheart.01395.2006

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Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider