Key result
In endothelial cells, angiotensin (1-7) counteracts the inhibitory effects of angiotensin II on insulin-induced Akt/eNOS activation and NO production via the Mas receptor.
Why the study?
Does angiotensin (1-7) counteract the negative effects of angiotensin II on insulin signalling in endothelial cells?
Population
Human umbilical vein endothelial cells (HUVECs) and mesenteric arteries of mice
Comparison
Angiotensin (1-7) vs Angiotensin II alone
Design
Preclinical
Authors
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May protect endothelial insulin signaling in vitro; hypothesis-generating for Mas agonism in human vascular insulin resistance.
Does angiotensin (1-7) counteract the negative effects of angiotensin II on insulin signalling in endothelial cells?
Angiotensin (1-7) counteracts the negative effects of angiotensin II on insulin signalling and NO production in endothelial cells, suggesting a protective role against endothelial dysfunction and insulin resistance.
Tassone et al. (2013) studied Endothelial dysfunction and insulin resistance. Angiotensin (1-7) vs. Angiotensin II was evaluated on Insulin-induced Akt and eNOS phosphorylation, NO production, and serine phosphorylation of IRS1. In endothelial cells, angiotensin (1-7) counteracts the inhibitory effects of angiotensin II on insulin-induced Akt/eNOS activation and NO production via the Mas receptor.
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