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April 1, 2005Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Mechanisms of Reactive Oxygen Species–Dependent Downregulation of Insulin Receptor Substrate-1 by Angiotensin II

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Why the study?

Does Angiotensin II induce IRS-1 degradation and impair insulin signaling in vascular smooth muscle cells?

Population

Vascular smooth muscle cells (VSMCs)

Comparison

Angiotensin II (100 nmol/L for 18 hours) vs Untreated control (implied)

Design

Preclinical

Follow-up

18 hours

Authors

YTYoshihiro TaniyamaKansai Medical UniversityHHHirofumi HitomiKansai Medical UniversityASAnand S. ShahRutgers, The State University of New Jersey

Discussion

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Member takes

Overview

May explain Ang II effects on vascular insulin signaling in animals; leaves open translation to ARB metabolic benefits in humans.

Structured PICO

Does Angiotensin II induce IRS-1 degradation and impair insulin signaling in vascular smooth muscle cells?

P
Population
Vascular smooth muscle cells (VSMCs)
I
Intervention
Angiotensin II (100 nmol/L for 18 hours)
C
Comparator
Untreated control (implied)
O
Outcome
IRS-1 phosphorylation on Ser307 and protein degradationsurrogate

Angiotensin II impairs insulin signaling in vascular smooth muscle cells by promoting ROS-dependent IRS-1 degradation, providing a molecular mechanism for the beneficial metabolic effects of angiotensin receptor blockers.

Cite This Study

Taniyama et al. (2005) studied this question.

synapsesocial.com/papers/6a7d8613968fa26fcacb49bdhttps://doi.org/10.1161/01.atv.0000164313.17167.df
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of NADH/NADPH Oxidase–Derived H<sub>2</sub>O<sub>2</sub>in Angiotensin II–Induced Vascular Hypertrophy1998 · 616 citations
  2. 2Angiotensin II Activates pp60<sup>c-</sup><sup>src</sup>in Vascular Smooth Muscle Cells1995 · 168 citations
  3. 3Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex2002 · 765 citations
  4. 4Serine/Threonine Phosphorylation of IRS-1 Triggers Its Degradation2001 · 299 citations
  5. 5Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes1999 · 302 citations