February 11, 2005EndocrinologyOpen Access

Angiotensin II Enhances Insulin Sensitivity in Vitro and in Vivo

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Why the study?

Does angiotensin II enhance insulin sensitivity in isolated rat adipocytes and Sprague Dawley rats?

Population

Isolated rat adipocytes and Sprague Dawley rats

Comparison

Angiotensin II (AII) vs Basal state / no Angiotensin II

Design

Preclinical

Authors

CJChi‐Chang JuanNational Yang Ming Chiao Tung University YCYueh ChienNational Yang Ming Chiao Tung University LWLiang‐Yi WuChung Yuan Christian University

Discussion

Member takes

Implication

Hypothesis-generating in rodents; leaves open any human relevance or therapeutic implications.

Structured PICO

Does angiotensin II enhance insulin sensitivity in isolated rat adipocytes and Sprague Dawley rats?

Population

Isolated rat adipocytes and Sprague Dawley rats

Intervention

Angiotensin II (AII)

Comparator

Basal state / no Angiotensin II

Outcome

Insulin sensitivity (measured by glucose uptake, insulin receptor beta-subunit tyrosine phosphorylation, Akt phosphorylation, and GLUT4 translocation)surrogate

Angiotensin II enhances insulin sensitivity both in vitro and in vivo, suggesting that dysregulation of this effect may be involved in the development of insulin resistance.

Cite This Study

Juan et al. (2005) studied this question.

synapsesocial.com/papers/6a702b3f2163a0a01bc46307 https://doi.org/10.1210/en.2004-1136

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Angiotensin II Enhances Insulin Sensitivity in Vitro and in Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Enhances Insulin Sensitivity in Vitro and in Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider