Why the study?
Does Western blotting or ELISA using recombinant N and S proteins accurately detect antibodies in SARS-CoV infected patients?
Population
40 SARS-CoV-infected patients in the convalescent phase and 12 RT-PCR-confirmed SARS patients
Design
Other
Follow-up
mean of 16 days after onset of fever (for seroconversion)
Authors
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Supports N protein ELISA for SARS-CoV serology; leaves open prospective validation before diagnostic adoption.
Does Western blotting or ELISA using recombinant N and S proteins accurately detect antibodies in SARS-CoV infected patients?
Antibodies against SARS-CoV N protein appear early in infection, making N protein-based ELISA a potentially sensitive and specific diagnostic test.
Huang et al. (2004) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: