What question did this study set out to answer?

To evaluate the teratogenic effects and critical developmental timing of epinephrine administration on aortic arch and cardiac morphogenesis in chick embryos.

April 1, 1974Teratology

Aortic arch anomalies associated with the administration of epinephrine in chick embryos

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To evaluate the teratogenic effects and critical developmental timing of epinephrine administration on aortic arch and cardiac morphogenesis in chick embryos.
Administered single doses of epinephrine (5 μg) in ovo onto the extraembryonic membrane across 83 groups of chick embryos (incubated 24–190 h) at 2-h intervals.
The peak incidence of aortic arch anomalies reached 94% following epinephrine administration during day 5 of incubation (108–112 h).
Observed vascular anomalies involved the 3rd, 4th, and 6th pairs of aortic arches, with malformations of the right 4th arch (arcus aortae) consistently associated with ventricular septal defects.

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Implication

Experimental study reveals epinephrine induces aortic arch anomalies and septal defects in chick embryos, indicating a critical window of vulnerability during cardiovascular morphogenesis.

Cite This Study

Hodach et al. (1974) studied this question.

synapsesocial.com/papers/6a702d2831a3df82432873a5 https://doi.org/10.1002/tera.1420090211

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Implication

Experimental study reveals epinephrine induces aortic arch anomalies and septal defects in chick embryos, indicating a critical window of vulnerability during cardiovascular morphogenesis.

Aortic arch anomalies associated with the administration of epinephrine in chick embryos

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Discussion

Implication

Cite This Study

Aortic arch anomalies associated with the administration of epinephrine in chick embryos

Key Points

Discussion

Implication

Cite This Study

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