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August 8, 2015DiabetologiaOpen Access

Central administration of exendin-4 increased sympathetic outflow towards BAT and increased the uptake of plasma TG-derived fatty acids and glucose by BAT, accompanied by lower plasma TG and glucose concentrations and reduced body weight.

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Why the study?

Does 5 day intracerebroventricular infusion of exendin-4 improve lipid and glucose uptake by brown adipose tissue in lean and diet-induced obese C57Bl/6J mice?

Population

Lean and diet-induced obese (DIO) C57Bl/6J mice

Comparison

5 day intracerebroventricular infusion of the… vs Vehicle

Design

Preclinical

Follow-up

5 days

Authors

SKSander KooijmanYWYanan WangEPEdwin T. Parlevliet

Discussion

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Overview

Central GLP-1R activation may boost BAT substrate clearance in rodents; hypothesis-generating for human metabolic therapies, needs clinical trials.

Structured PICO

Does 5 day intracerebroventricular infusion of exendin-4 improve lipid and glucose uptake by brown adipose tissue in lean and diet-induced obese C57Bl/6J mice?

P
Population
Lean and diet-induced obese (DIO) C57Bl/6J mice
I
Intervention
5 day intracerebroventricular infusion of the GLP-1 analogue exendin-4
C
Comparator
Vehicle
O
Outcome
Lipid and glucose uptake by brown adipose tissue (BAT)surrogate

Central GLP-1 receptor activation by exendin-4 lowers plasma triglycerides and glucose by increasing sympathetic outflow and activating brown adipose tissue in mice.

Cite This Study

Kooijman et al. (2015) studied this question.

synapsesocial.com/papers/6a702e4c5d37378ac1dd3ffbhttps://doi.org/10.1007/s00125-015-3727-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat2025 · 8 citations
  2. 2GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation2017 · 127 citations
  3. 3Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males2020 · 54 citations
  4. 4Exendin-4 Improves Diabetic Kidney Disease in C57BL/6 Mice Independent of Brown Adipose Tissue Activation2020 · 17 citations
  5. 5Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity2008 · 121 citations