October 29, 2014Socio-Environmental Systems ModelingOpen Access

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

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Population

Male C57Bl/6J mice

Design

Preclinical

Authors

PKPadmini P. S. J. KhedoeLeiden University Medical Center GHGeerte HoekeLeiden University Medical Center SKSander KooijmanLeiden University Medical Center

Discussion

Member takes

Implication

May inform BAT-targeted dyslipidemia research; leaves open human translation of preferential lipolysis-mediated TG uptake.

Structured PICO

Population

Male C57Bl/6J mice

Intervention

Intravenous injection of glycerol tri[(3)H]oleate and [(14)C]cholesteryl oleate double-labeled TRL-mimicking particles (45, 80, and 150 nm) and exposure to different temperatures (21°C, 7°C, 28°C)

Outcome

Uptake of (3)H-activity (fatty acids) versus (14)C-activity (cholesteryl ester) by brown adipose tissuesurrogate

Brown adipose tissue takes up plasma triglycerides primarily through lipolysis-mediated uptake of fatty acids rather than whole particle uptake.

Cite This Study

Khedoe et al. (2014) studied this question.

synapsesocial.com/papers/6a702e4c5d37378ac1dd3ffc https://doi.org/10.1194/jlr.m052746

View Full Paper

Ask AI

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Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider