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October 1, 2001Journal of Lipid ResearchOpen Access

Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice

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Why the study?

Does apolipoprotein C-III deficiency accelerate triglyceride hydrolysis and lower lipids in wild-type and apoE knockout mice?

Population

Wild-type and apoE knockout (apoE-/-) mice

Comparison

Apolipoprotein C-III deficiency vs Mice with normal apoC-III expression

Design

Preclinical

Authors

MJMiek C. JongNetherlands Organisation for Applied Scientific ResearchPRPatrick C.N. RensenLeiden University Medical CenterVDVivian E.H. DahlmansMaastricht University

Discussion

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Implication

May support apoC-III inhibition for hypertriglyceridemia; hypothesis-generating in mice, leaves human translation open.

Structured PICO

Does apolipoprotein C-III deficiency accelerate triglyceride hydrolysis and lower lipids in wild-type and apoE knockout mice?

P
Population
Wild-type and apoE knockout (apoE-/-) mice
I
Intervention
Apolipoprotein C-III (apoC-III) deficiency (apoC3-/- knockout)
C
Comparator
Mice with normal apoC-III expression
O
Outcome
VLDL cholesterol and triglyceride (TG) levels, and clearance rates of TG-labeled emulsion particlessurrogate

Apolipoprotein C-III deficiency lowers lipids by accelerating VLDL triglyceride hydrolysis and enhancing selective clearance of VLDL cholesteryl esters, independent of apoE.

Cite This Study

Jong et al. (2001) studied this question.

synapsesocial.com/papers/6a7725b22e130d02afec65fchttps://doi.org/10.1016/s0022-2275(20)32211-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.1982 · 132 citations
  2. 2Inhibitory Effects of Specific Apolipoprotein C-III Isoforms on the Binding of Triglyceride-rich Lipoproteins to the Lipolysis-stimulated Receptor1997 · 78 citations
  3. 3In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.1996 · 117 citations
  4. 4Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo.1986 · 427 citations
  5. 5Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.1985 · 416 citations