Why the study?
Does apolipoprotein CIII overexpression increase arteriosclerosis in apolipoprotein E-null mice?
Population
apoCIII transgenic and apoE gene knockout (apoE0) mice
Comparison
apolipoprotein CIII overexpression vs apoE0 mice
Design
Preclinical
Authors
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Severe hypertriglyceridemia from apoCIII overexpression does not increase arteriosclerosis in apoE-null mice; leaves open its role in human atherosclerosis.
Does apolipoprotein CIII overexpression increase arteriosclerosis in apolipoprotein E-null mice?
ApoCIII overexpression induces severe hypertriglyceridemia via decreased lipolysis at the cell surface, but these very large triglyceride-enriched particles are not directly atherogenic in apoE-null mice.
Ebara et al. (1997) studied this question.
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