Why the study?
Does apo C-III deficiency affect triglyceride secretion rate and turnover in mice?
Population
Apo C-III gene-disrupted (apo C-III-null) mice, apo E-null mice, and wild-type (WT) mice
Comparison
Apo C-III deficiency and/or… vs Wild-type (WT) mice
Design
Preclinical
Authors
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Apo C-III deficiency may enhance TG turnover in obese models; hypothesis-generating for human relevance and should not change practice.
Does apo C-III deficiency affect triglyceride secretion rate and turnover in mice?
Apo C-III deficiency potently enhances triglyceride turnover, particularly when triglyceride production is stimulated by obesity.
Hirano et al. (2001) studied this question.
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