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June 1, 1996Journal of Biological ChemistryOpen Access

Apolipoprotein E Effectively Inhibits Lipoprotein Lipase-mediated Lipolysis of Chylomicron-like Triglyceride-rich Lipid Emulsions and

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Why the study?

Does Apolipoprotein E inhibit lipoprotein lipase-mediated lipolysis of triglyceride-rich lipid emulsions in vitro and in vivo?

Population

Fasted rats (functionally hepatectomized with hypolipoproteinemia induced by 17alpha-ethinyl estradiol) and…

Comparison

Exogenous Apolipoprotein E (apoE) vs Absence of exogenous apoE, apoA-I, or modified…

Design

Preclinical

Authors

PRPatrick C.N. RensenLeiden University Medical CenterTBTheo J.C. van BerkelGeneral / Preventive / Lipids

Discussion

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Implication

ApoE may modulate triglyceride-rich lipoprotein clearance; leaves open its relevance to human dyslipidemia and requires clinical studies.

Structured PICO

Does Apolipoprotein E inhibit lipoprotein lipase-mediated lipolysis of triglyceride-rich lipid emulsions in vitro and in vivo?

P
Population
Fasted rats (functionally hepatectomized with hypo(apo)lipoproteinemia induced by 17alpha-ethinyl estradiol) and in vitro purified lipoprotein lipase with triglyceride-rich emulsions
I
Intervention
Exogenous Apolipoprotein E (apoE)
C
Comparator
Absence of exogenous apoE, apoA-I, or modified apoE (reductive methylation of lysine residues vs selective modification of arginine residues)
O
Outcome
Lipoprotein lipase (LPL)-mediated hydrolysis of emulsion triglycerides (measured by serum half-life of glycerol tri[3H]oleate and [3H]oleate release)surrogate

Apolipoprotein E specifically inhibits LPL-mediated hydrolysis of emulsion triglycerides, suggesting a modulatory role in triglyceride-rich lipoprotein processing beyond receptor recognition.

Cite This Study

Rensen et al. (1996) studied this question.

synapsesocial.com/papers/6a702e4e5d37378ac1dd4007https://doi.org/10.1074/jbc.271.25.14791
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New Aspects on Heparin and Lipoprotein Metabolism2009 · 40 citations
  2. 2Kinetics of lipolysis of very low density lipoproteins by lipoprotein lipase. Importance of particle number and noncompetitive inhibition by particles with low triglyceride content.1994 · 44 citations
  3. 3Lipoprotein lipase-catalyzed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism1983 · 19 citations
  4. 4Interchange of Apolipoproteins between Chylomicrons and High Density Lipoproteins during Alimentary Lipemia in Man1973 · 529 citations
  5. 5The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase1993 · 199 citations