Population
Nascent very-low-density-lipoprotein (VLDL) obtained by liver perfusions from apoE-deficient mice
Comparison
Addition of increasing amounts of apolipoprotein E vs ApoE-deficient nascent VLDL without the addition…
Design
Preclinical
Authors
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May inhibit VLDL lipolysis in animal models; leaves open its role in human dyslipidemia.
Enrichment of VLDL particles with apoE decreases their suitability as a substrate for lipoprotein lipase in a dose-dependent manner, suggesting an inhibitory role for apoE in VLDL triacylglycerol hydrolysis.
Jong et al. (1997) studied this question.
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