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February 13, 2001Proceedings of the National Academy of SciencesOpen Access

A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V

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Population

GP V-null mice, wild-type mice, and human platelets

Comparison

Proteolytically inactive thrombin and active… vs Wild-type vs GP V null genotypes

Design

Preclinical

Authors

VRVanitha RamakrishnanFDFrancis DeGuzmanMBMing Bao

Discussion

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Overview

No immediate clinical implications; leaves open proteolytic-independent thrombin signaling in human thrombosis.

Structured PICO

P
Population
GP V-null mice, wild-type mice, and human platelets
I
Intervention
Proteolytically inactive thrombin and active thrombin
C
Comparator
Wild-type vs GP V null genotypes
O
Outcome
Platelet activation and thrombosis generationsurrogate

The study identifies a novel thrombin signaling mechanism where the GP Ib-IX-V complex acts as a thrombin receptor after GP V cleavage, leading to platelet activation.

Cite This Study

Ramakrishnan et al. (2001) studied this question.

synapsesocial.com/papers/6a702ead5671bbf00bc2a970https://doi.org/10.1073/pnas.98.4.1823
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Analyses of the Platelet Glycoprotein Ib-IX-V Receptor1998 · 55 citations
  2. 2Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation2015 · 280 citations
  3. 3Thrombin Interaction With Platelet Membrane Glycoprotein Ib1996 · 24 citations
  4. 4GPIbα-selective activation of platelets induces platelet signaling events comparable to GPVI activation events2010 · 52 citations
  5. 5Thrombin binding to GPIbα induces platelet aggregation and fibrin clot retraction supported by resting αIIbβ3 interaction with polymerized fibrin2003 · 34 citations