January 1, 1996Journal of NeuroscienceOpen Access

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

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Population

PC12 cells

Comparison

Downregulation of Cu/Zn superoxide dismutase… vs Withdrawal of trophic support

Design

Preclinical

Authors

CTCM TroyColumbia University DDDaniele DerossiGuy's Hospital APAlain ProchiantzCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Does not support clinical translation; leaves open relevance of peroxynitrite pathway to in vivo models.

Structured PICO

Population

PC12 cells

Intervention

Downregulation of Cu/Zn superoxide dismutase (SOD1) activity using an antisense oligonucleotide coupled to a carrier vector peptide homologous to the third helix of the Drosophila Antennapedia homeodomain

Comparator

Withdrawal of trophic support (nerve growth factor)

Outcome

Pathways of apoptotic cell deathsurrogate

SOD1 downregulation triggers apoptosis in PC12 cells via the nitric oxide-peroxynitrite pathway, which is distinct from the initial mechanisms of trophic support withdrawal but may share a common final pathway.

Cite This Study

Troy et al. (1996) studied this question.

synapsesocial.com/papers/6a702efdfe4101aa97e00c0a https://doi.org/10.1523/jneurosci.16-01-00253.1996

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Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider