May 28, 1996Proceedings of the National Academy of SciencesOpen Access

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

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Population

PC12 cells

Design

Preclinical

Authors

CTCarol M. TroyTunghai University LSLeonidas StefanisNational and Kapodistrian University of Athens APAlain ProchiantzCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Differentiates IL-1beta-dependent from independent apoptosis; leaves open selective ICE targeting in neurodegeneration models.

Structured PICO

Population

PC12 cells

Intervention

ICE family protease inhibitors (novel peptide inhibitor mimicking catalytic site, permeant competitive antagonist), IL-1beta blocking antibodies, and IL-1 receptor antagonist (IL-1Ralpha)

Outcome

Apoptotic cell death induced by down-regulation of Cu2+,Zn2+ superoxide dismutase (SOD1) or withdrawal of trophic supportsurrogate

This preclinical study demonstrates that while ICE family proteases are involved in apoptosis from both oxidative stress and trophic factor withdrawal, the specific pathways and substrates (such as IL-1beta) differ between the two mechanisms.

Cite This Study

Troy et al. (1996) studied this question.

synapsesocial.com/papers/6a7d82f8e472e2eab1a2926b https://doi.org/10.1073/pnas.93.11.5635

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The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider