Why the study?
Can ultrasound elasticity imaging detect differences in arterial compliance and renal mechanical properties in patients with ESRD or renal transplants compared to controls?
Can ultrasound elasticity imaging detect differences in arterial compliance and renal mechanical properties in patients with ESRD or renal transplants compared to controls?
Ultrasound elasticity imaging can noninvasively detect reduced arterial compliance in ESRD patients and altered mechanical properties in chronic allograft nephropathy.
Ultrasound elasticity imaging detects reduced arterial compliance in ESRD; hypothesis-generating for noninvasive vascular assessment pending prospective validation.
BACKGROUND/AIMS: Ultrasound elasticity imaging visually represents tissue hardness measurements using high-resolution ultrasound speckle-tracking algorithms. This method has recently been applied in the renal setting to measure arterial compliance in end-stage renal disease (ESRD) and the mechanical properties of transplant kidneys in vivo. METHODS: Ultrasound radio-frequency signal measurements were made of the brachial artery in 5 ESRD subjects and 5 healthy controls and renal transplant measurements in 2 subjects, 1 with chronic allograft nephropathy (CAN) and 1 with normal graft function. RESULTS: Maximal brachial artery percent strain measurements for healthy controls were 32.9 +/- 10.2% (mean +/- SD) and for ESRD subjects maximal percent strains were 4.9 +/- 1.8%. Transplant renal cortical strain for the subject with CAN was approximately one third that of the healthy transplant recipient. CONCLUSION: Ultrasound elasticity imaging offers the potential to noninvasively measure the mechanical properties of structures within the body.
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Weitzel et al. (2004) studied this question.
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