Key result
ARFI-based tissue elasticity shows a ~15% increase in acute transplant rejection versus other pathologies.
Why the study?
Experience with ARFI-based tissue elasticity quantification in renal transplant follow-up had not been reported, limiting non-invasive assessment of allograft dysfunction.
Does ARFI-based tissue elasticity quantification detect acute rejection in renal transplant patients?
Population
8 renal transplant patients
Comparison
ARFI measurements during stable allograft function vs transplant dysfunction
Design
Prospective cohort study with blinded histopathological evaluation
Authors
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ARFI-based elasticity measurement shows promise as a complementary non-invasive parameter for diagnosing renal allograft rejection.
Cohort (n=8)
Single-blind
Does ARFI-based tissue elasticity quantification detect acute rejection in renal transplant patients?
ARFI-based elasticity measurement shows promise as a complementary non-invasive parameter for diagnosing renal allograft rejection.
Stock et al. (2011) conducted a cohort in Renal allograft dysfunction (n=8). ARFI-based tissue elasticity quantification vs. Other pathologies (calcineurin inhibitor toxicity, acute tubular necrosis) was evaluated on Changes in ARFI-measurements between clinically stable renal allografts and biopsy-proven transplant dysfunction. ARFI-based tissue elasticity quantification showed an average increase of >15% in transplants with acute rejection, whereas no increase was seen in other pathologies.
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