February 15, 1993BloodOpen Access

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

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Population

A patient with a mild bleeding disorder whose platelets responded defectively to thromboxane A2 (TXA2) (n=1)

Design

Case_report

Authors

IFIkuya FUSENiigata University MMM MitoNiigata University AHAkira HattoriKyoto Pharmaceutical University

Discussion

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Implication

Impaired TXA2 receptor-PLC coupling may define a novel platelet defect; hypothesis-generating for separable PLA2/PLC pathways in thromboxane signaling.

Structured PICO

Population

A patient with a mild bleeding disorder whose platelets responded defectively to thromboxane A2 (TXA2) (n=1)

Intervention

In vitro challenge of platelets with synthetic TXA2 mimetic (STA2)

Outcome

Mechanism of platelet dysfunction (including receptor binding capacity, IP3 formation, intracellular Ca2+ mobilization, GTPase activity, and PLA2 activation)surrogate

This mechanistic case study suggests that the activation of phospholipase A2 and phospholipase C are separable events in thromboxane-induced platelet activation.

Cite This Study

FUSE et al. (1993) studied this question.

synapsesocial.com/papers/6a702f1db5c1fe5ca9dfac65 https://doi.org/10.1182/blood.v81.4.994.bloodjournal814994

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Implication

Impaired TXA2 receptor-PLC coupling may define a novel platelet defect; hypothesis-generating for separable PLA2/PLC pathways in thromboxane signaling.

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider