September 1, 1981British Journal of Haematology

Familial Bleeding Tendency with Partial Platelet Thromboxane Synthetase Deficiency: Reorientation of Cyclic Endoperoxide Metabolism

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Population

3 family members from three successive generations presenting with a moderate bleeding tendency and a…

Design

Case_series

Authors

GDG. DefreynVisteon (South Korea)SMS.J. MachinHospital Universitario Insular de Gran Canaria LCL CarrerasInserm

Discussion

Member takes

Implication

Supports investigation of thromboxane defects in unexplained bleeding; leaves open prevalence and causality in larger cohorts.

Structured PICO

Population

3 family members from three successive generations presenting with a moderate bleeding tendency and a functional platelet defect.

Outcome

Platelet aggregation and cyclic endoperoxide metabolism (including thromboxane B2, malondialdehyde, and prostaglandin levels)surrogate

A familial bleeding tendency was linked to a partial platelet thromboxane synthetase deficiency, leading to reduced thromboxane A2 and increased aggregation-inhibiting prostaglandins.

Cite This Study

Defreyn et al. (1981) studied this question.

synapsesocial.com/papers/6a9039532a22b8e8a92da435 https://doi.org/10.1111/j.1365-2141.1981.tb07194.x

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Familial Bleeding Tendency with Partial Platelet Thromboxane Synthetase Deficiency: Reorientation of Cyclic Endoperoxide Metabolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Familial Bleeding Tendency with Partial Platelet Thromboxane Synthetase Deficiency: Reorientation of Cyclic Endoperoxide Metabolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider