Why the study?
Patients with mitral valve prolapse (MVP) have reported exercise intolerance, but the underlying pathophysiological mechanisms and their physical fitness remain unclear.
Does cardiopulmonary exercise capacity differ between pediatric patients with mitral valve prolapse and healthy peers?
Does cardiopulmonary exercise capacity differ between pediatric patients with mitral valve prolapse and healthy peers?
Pediatric patients with mitral valve prolapse have preserved exercise capacity but exhibit a reduced peak rate pressure product, which may indicate subtle left ventricular function impairment.
Challenges prior reports of MVP exercise intolerance; leaves open confirmation in prospective studies.
Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET). We retrospectively collected the data of 45 patients with a diagnosis of MVP. Their CPET and echocardiogram results were compared with 76 healthy individuals as primary outcomes. No significant differences regarding the patient’s baseline characteristics and echocardiographic data were found between the two groups, except for the lower body mass index (BMI) of the MVP group. Patients in the MVP group demonstrated a similar peak metabolic equivalent (MET), but a significantly lower peak rate pressure product (PRPP) (p = 0.048). Patients with MVP possessed similar exercise capacity to healthy individuals. The reduced PRPP may indicate compromised coronary perfusion and subtle left ventricular function impairment.
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Huang et al. (2023) studied this question.
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