Why the study?
Does membrane depolarization affect the initiation of acetylcholine-induced Ca2+ transients in isolated guinea pig coronary myocytes?
Population
Isolated guinea pig coronary arterial smooth muscle cells
Comparison
Membrane depolarization to +50 mV during… vs Membrane potential of -50 mV during ACh…
Design
Preclinical
Authors
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No immediate clinical implications from guinea pig myocytes; leaves open voltage-dependent Ca2+ modulation in intact coronary vessels.
Does membrane depolarization affect the initiation of acetylcholine-induced Ca2+ transients in isolated guinea pig coronary myocytes?
Membrane depolarization accelerates the initiation and rate of rise of acetylcholine-induced Ca2+ transients in coronary myocytes, likely due to increased IP3 accumulation.
Ganitkevich et al. (1996) studied this question.
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