Population
Isolated smooth muscle cells dispersed from the circumflex coronary artery of the guinea pig
Comparison
Acetylcholine (10 microM) bath application vs Baseline conditions and application of blockers
Design
Preclinical
Authors
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Does not alter clinical coronary tone management; leaves open translation of this SR-calcium-K+ pathway from guinea pig models.
In guinea pig coronary smooth muscle cells, acetylcholine induces hyperpolarization by triggering calcium release from the sarcoplasmic reticulum, which activates calcium-dependent potassium channels.
Ganitkevich et al. (1990) studied this question.
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