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LDH isoenzymes may aid AMI diagnosis where troponin is unavailable; leaves open their role versus modern biomarkers in updated guidelines.
Biochemical TechnicsIt has been known for over 20 years that irreversibly injured myocardial cells release enzymes. In the hours after an acute myocardial infarction, the plasma concentrations of these enzymes gradually rise, reach a peak and then fall progressively. The laboratory measurement of serum enzymes is a standard practice in the diagnosis of acute myocardial infarction. Lactic dehydrogenase (LDH) is elevated in the several days after an acute myocardial infarction; this enzyme can be separated into five distinct components or isoenzymes, according to their speed of migration in an electrophoretic field. The myocardium contains predominantly LDH5, although . . .
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Hillis et al. (1977) studied this question.
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