Prostacyclin (PGI2) does not directly affect myocardial contractility in isolated mammalian cardiac muscle.
PGI2-isoproterenol combinations remain uncontraindicated by direct effects; leaves open translation to human myocardium.
We studied the influence of prostacyclin (PGI2) on the contractile performance of isolated mammalian ventricular muscle. PGI2 had no direct influence on myocardial contractility, as evidenced by experiments on single cardiac cells and papillary muscle. Moreover, PGI2 did not interfere with the inotropic action of isoproterenol. In comparison, neither prostaglandin E1 nor E2 appeared to have any cardiotonic action.
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Couttenye et al. (1985) studied this question.
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