December 8, 2011Circulation Cardiovascular Imaging

Cardiac Myosin Binding Protein C Insufficiency Leads to Early Onset of Mechanical Dysfunction

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Why the study?

Does cMyBPC insufficiency lead to early-onset mechanical dysfunction in a mouse model?

Population

Young mice carrying no functional cMyBPC alleles (cMyBPC) or 1 functional cMyBPC allele (cMyBPC)

Comparison

Genetic mutation causing cMyBPC insufficiency… vs Wild-type (WT) mice

Design

Preclinical

Authors

CDCandida L. DesjardinsCollege of the Holy Cross YCYong ChenNingxia Medical University ACArthur T. CoultonCase Western Reserve University

Discussion

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Implication

Subtle LV strain reductions emerge with modest cMyBPC loss in mice; hypothesis-generating for early HCM mechanisms in humans.

Structured PICO

Does cMyBPC insufficiency lead to early-onset mechanical dysfunction in a mouse model?

Population

Young mice (8-10 weeks of age) carrying no functional cMyBPC alleles (cMyBPC(-/-)) or 1 functional cMyBPC allele (cMyBPC(±))

Intervention

Genetic mutation causing cMyBPC insufficiency (cMyBPC(-/-) or cMyBPC(±))

Comparator

Wild-type (WT) mice

Outcome

Cardiac mechanical function in vitro (stretch activation cross-bridge kinetics in skinned myocardium) and in vivo (LV magnitude, rates of LV wall strain and torsion via cardiac MRI)surrogate

Modest decreases in cMyBPC expression in mice cause early-onset subtle changes in cross-bridge kinetics and LV mechanical function, potentially contributing to later HCM development.

Cite This Study

Desjardins et al. (2011) studied this question.

synapsesocial.com/papers/6a70373335aa2c282ce18450 https://doi.org/10.1161/circimaging.111.965772

Topics

Hypertrophic cardiomyopathy

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Cardiac Myosin Binding Protein C Insufficiency Leads to Early Onset of Mechanical Dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac Myosin Binding Protein C Insufficiency Leads to Early Onset of Mechanical Dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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