What is the clinical evidence from this study?

Population: Hypertrophic cardiomyopathy. Intervention: Mybpc3 mutation vs. Wild-type mice. Primary outcome: Myofilament Ca2+ sensitivity, diastolic dysfunction, and left ventricular hypertrophy.

March 23, 2012Journal of Molecular and Cellular CardiologyOpen Access

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

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Key result

Heterozygous Mybpc3 knock-in drives higher Ca2+ sensitivity and diastolic dysfunction independent of LVH in mice.

Structured PICO

Population

10-week old homozygous and heterozygous Mybpc3-targeted knock-in mice compared to wild-type mice to study hypertrophic cardiomyopathy.

Exposure

Mybpc3 point mutation (homozygous and heterozygous)

Comparator

Wild-type mice

Outcome

Myofilament Ca2+ sensitivity, diastolic function (diastolic sarcomere length, Ca2+ transient decay, echocardiography/Doppler parameters), and left ventricular hypertrophysurrogate

Myofilament Ca2+ sensitization and diastolic dysfunction are early phenotypic consequences of Mybpc3 mutations that precede the development of left ventricular hypertrophy in hypertrophic cardiomyopathy.

Discussion

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Implication

Suggests diastolic dysfunction precedes hypertrophy in Mybpc3 HCM; leaves open whether Ca2+ sensitization is a viable early target in patients.

Cite This Study

Fraysse et al. (2012) studied Hypertrophic cardiomyopathy. Mybpc3 mutation vs. Wild-type mice was evaluated on Myofilament Ca2+ sensitivity, diastolic dysfunction, and left ventricular hypertrophy. Heterozygous Mybpc3 knock-in mice exhibited higher myofilament Ca2+ sensitivity, faster Ca2+ transient decay, and diastolic dysfunction independent of left ventricular hypertrophy.

synapsesocial.com/papers/6aa39250d5ccfe0ebfb71c65 https://doi.org/10.1016/j.yjmcc.2012.03.009

Topics

Echocardiography Hypertrophic cardiomyopathy

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Implication

Suggests diastolic dysfunction precedes hypertrophy in Mybpc3 HCM; leaves open whether Ca2+ sensitization is a viable early target in patients.

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Structured PICO

Discussion

Implication

Cite This Study

Topics

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider