Alzheimer disease (AD) is a progressive degenerative disease that manifests as gradual deterioration in memory and cognition, behavior, and the ability to perform activities of daily living. Accurate diagnosis and continued evaluation of these aspects of AD can help guide therapy for patients in the late stage of the disease. Assessment tools specific for patients with severe AD are available for use in clinical studies.
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Ferris et al. (2003) studied this question.
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