Why the study?
Do arrhythmogenic drugs amplify spatial heterogeneities in electrical restitution in perfused guinea-pig hearts?
Do arrhythmogenic drugs amplify spatial heterogeneities in electrical restitution in perfused guinea-pig hearts?
Arrhythmogenic drugs amplify regional heterogeneities in APD90 restitution, which can be indirectly assessed via ECG measurements of JTend vs. JTpeak dynamics.
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May heighten arrhythmia risk assessment caution with these drugs; leaves open clinical ECG translation from in vitro APD findings.
Oleg E. Osadchii (2018) studied this question.
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