Population
Normal human fibroblasts (in vitro model)
Comparison
Infection with mutant adenovirus with… vs Infection with wild-type adenovirus
Design
Preclinical
Authors
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Impaired E1B function in IFN-treated cells highlights viral evasion mechanisms; leaves open whether these residues represent viable antiviral targets.
The E1B 55-kDa protein of human adenovirus type 5 represses transcription of IFN-inducible genes to protect against inhibition of viral genome replication, though it is not sufficient alone to establish this repression.
Chahal et al. (2013) studied this question.
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