August 9, 2012PLoS PathogensOpen Access

The Human Adenovirus Type 5 E1B 55 kDa Protein Obstructs Inhibition of Viral Replication by Type I Interferon in Normal Human Cells

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Population

Normal human fibroblasts and respiratory epithelial cells infected with human adenovirus type 5

Comparison

Exogenous interferon (IFN) vs Absence of exogenous interferon (IFN)

Design

Preclinical

Authors

JCJasdave S. ChahalToshiba (United States)JQJi QiJilin University SFS. J. FlintPrinceton University

Discussion

Member takes

Implication

E1B 55 kDa inhibition may enhance IFN activity against adenovirus; leaves open translation beyond animal models.

Structured PICO

Population

Normal human fibroblasts and respiratory epithelial cells infected with human adenovirus type 5 (wild-type or E1B 55 kDa null-mutants)

Intervention

Exogenous interferon (IFN)

Comparator

Absence of exogenous interferon (IFN)

Outcome

Viral replication (yields of mutants vs wild-type), accumulation of viral early proteins and genomes, and formation of viral replication centerssurrogate

The adenovirus E1B 55 kDa protein acts as a potent repressor of IFN-inducible genes, facilitating viral replication by blocking the antiviral effects of Type I interferon.

Cite This Study

Chahal et al. (2012) studied this question.

synapsesocial.com/papers/6a70384fce524a4339c3fb92 https://doi.org/10.1371/journal.ppat.1002853

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The Human Adenovirus Type 5 E1B 55 kDa Protein Obstructs Inhibition of Viral Replication by Type I Interferon in Normal Human Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Human Adenovirus Type 5 E1B 55 kDa Protein Obstructs Inhibition of Viral Replication by Type I Interferon in Normal Human Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider