Why the study?
Are drugs that block the renin-angiotensin system effective and safe in patients with renal insufficiency?
Population
Patients with renal insufficiency/disease, including diabetic and nondiabetic nephropathy
Design
Review
Authors
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Supports RAS blockade with monitoring in renal insufficiency; leaves open optimal use in advanced CKD.
Are drugs that block the renin-angiotensin system effective and safe in patients with renal insufficiency?
ACE inhibitors and ARBs are effective and generally safe for managing hypertension and proteinuria in patients with renal insufficiency, though monitoring of potassium and creatinine is required.
Matthew A. Weir (1999) studied this question.
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