Population
16 anesthetized cats (feline femoral arterial bed model)
Comparison
Noradrenaline-induced constriction under… vs Noradrenaline-induced constriction under…
Design
Preclinical
Authors
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These animal perfusion results warrant caution in extrapolating to clinical settings; leaves open the impact of flow conditions on vasoconstriction in humans.
The difference in noradrenaline-induced constrictor responses between constant flow and constant pressure perfusions depends mainly on smooth muscle relaxation caused by increased wall shear stress sensed by the endothelium.
Kartamyshev et al. (2006) studied this question.
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