Population
Anesthetized cats (superior mesenteric artery perfusion circuit)
Comparison
Nerve stimulation or norepinephrine infusion… vs Baseline conditions before L-NAME, and…
Design
Preclinical
Authors
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Supports shear-NO modulation of sympathetic vasoconstriction in feline models; leaves open human translation and mechanisms.
In a feline model, shear-dependent release of nitric oxide during vasoconstriction produces vasodilation by decreasing sympathetic nerve activity rather than acting directly on vascular smooth muscle.
Macedo et al. (1996) studied this question.
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