August 30, 2019Biomedicine & PharmacotherapyOpen Access

The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques

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Why the study?

This study investigated the value of ultrasound-targeted microbubble destruction (UTMD) to deliver an IL-8 monoclonal antibody to inhibit inflammatory responses and increase plaque stability in a rabbit model of atherosclerosis.

Does UTMD-delivered IL-8 monoclonal antibody reduce inflammation and increase plaque stability in a rabbit model of atherosclerosis?

Population

Sixty 4-week-old male New Zealand rabbits with an abdominal aortic atherosclerotic plaque model

Comparison

Targeted contrast agent carrying IL-8 monoclonal antibody vs normal saline vs pretreatment baseline

Design

Animal experimental study

Follow-up

26 weeks

Authors

HYHanning YangUniversity of Freiburg YSYue SunSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou)JWJia WeiAnhui Agricultural University

Discussion

Member takes

Implication

Should not change practice in atherosclerosis; hypothesis-generating for UTMD IL-8 delivery in plaque stabilization.

Structured PICO

Does UTMD-delivered IL-8 monoclonal antibody reduce inflammation and increase plaque stability in a rabbit model of atherosclerosis?

Population

60 4-week-old male New Zealand rabbits with an abdominal aortic atherosclerotic plaque model induced by high-fat diet, balloon-induced mechanical injury, and bovine serum albumin-induced immunological injury.

Intervention

Ultrasound-targeted microbubble destruction (UTMD) delivering an IL-8 monoclonal antibody, administered every 2 weeks for a total of four times.

Comparator

UTMD with normal saline (control group) and a pretreatment baseline group.

Outcome

Peak intensity (PI), microvessel density (MVD), and macrophage count at 26 weeks.surrogate

UTMD-delivered IL-8 monoclonal antibodies effectively alleviate inflammation and may promote plaque stabilization in an atherosclerotic rabbit model.

Cite This Study

Yang et al. (2019) studied this question.

synapsesocial.com/papers/6a7039bd5d37378ac1dd4f8d https://doi.org/10.1016/j.biopha.2019.109161

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The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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