August 1, 1981Proceedings of the National Academy of SciencesOpen Access

Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.

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Population

Cultured fibroblasts and gerbil fibroma cells; antibodies raised in rabbits against turkey gizzard smooth…

Design

Preclinical

Authors

PLPrimal de LanerolleUniversity of Illinois Chicago RARobert AdelsteinHeart Failure / Cardiomyopathy JFJames R. FeramiscoUniversity of California, Riverside

Discussion

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Implication

Supports MLCK-myosin proximity in fibroblasts; leaves open functional role in human cardiovascular contractility.

Structured PICO

Population

Cultured fibroblasts and gerbil fibroma cells; antibodies raised in rabbits against turkey gizzard smooth muscle myosin light chain kinase

Intervention

Affinity-purified antibodies to smooth muscle myosin light chain kinase

Outcome

Localization of myosin light chain kinase in nonmuscle cellssurrogate

Myosin light chain kinase and its substrate, myosin, are in close proximity in nonmuscle cells, supporting the hypothesis that MLCK regulates actin-myosin interactions.

Cite This Study

Lanerolle et al. (1981) studied this question.

synapsesocial.com/papers/6a703a2b5d37378ac1dd500f https://doi.org/10.1073/pnas.78.8.4738

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Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider