Why the study?
Does tiapamil reduce ambulatory intraarterial blood pressure and exercise-induced changes in blood pressure in hypertensive patients?
Does tiapamil reduce ambulatory intraarterial blood pressure and exercise-induced changes in blood pressure in hypertensive patients?
Tiapamil given twice daily moderately reduces 24-hour ambulatory blood pressure and dynamic exercise-induced blood pressure rises in hypertensive patients, similar to existing calcium-channel blockers.
May support tiapamil for ambulatory BP and dynamic exercise control in hypertension; extends calcium-channel blocker data but requires randomized trials.
The duration and magnitude of effect of a new calcium-channel blocker, tiapamil, given twice daily, was studied in 17 hypertensive patients using ambulatory intraarterial blood pressure recording. The drug produced moderate reductions of blood pressure throughout the 24-h cycle with slight reduction of effect before each dose. Ten patients reported side effects, and one withdrew as a result of these. Tiapamil attenuated the blood pressure rise during dynamic cycle ergometry but had no effect on the increase during isometric hand grip. We conclude that tiapamil is similar to existing calcium-channel blocking agents in lowering the blood pressure, but it does not appear to influence the response to isometric exercise in this dose.
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Caruana et al. (1986) studied this question.
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