What question did this study set out to answer?

To evaluate whether patients with subclinical hypothyroidism have peripheral cardiac abnormalities that normalize following L-thyroxine replacement therapy.

December 1, 1981The Journal of Clinical Endocrinology & MetabolismOpen Access

Peripheral Responses to Thyroid Hormone before and after L-Thyroxine Therapy in Patients with Subclinical Hypothyroidism*

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Authors

ERE. Chester Ridgway DCDavid S. Cooper HWHarriet Walker

Discussion

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Overview

Interventional study reveals improved cardiac systolic time intervals with levothyroxine in subclinical hypothyroidism, indicating tissue-level hormone deficiency.

Key Points

To evaluate whether patients with subclinical hypothyroidism have peripheral cardiac abnormalities that normalize following L-thyroxine replacement therapy.
Assessed 20 patients presenting with elevated serum TSH levels but normal serum T4 and T3 concentrations before and after treatment with L-thyroxine.
Measured circulating thyroid hormone concentrations alongside noninvasive cardiac systolic time intervals, including preejection period and arterial pulse arrival time (QKd).
L-thyroxine therapy increased serum T4 from 5.5 ± 1.1 to 8.8 ± 1.8 µg/dl and serum T3 from 116 ± 20 to 137 ± 28 ng/dl.
Cardiac systolic time intervals significantly decreased (P < 0.01), with the preejection period declining from 123 ± 18 to 114 ± 14 msec (n = 12) and the preejection period to left ventricular ejection time ratio decreasing from 0.412 ± 0.068 to 0.357 ± 0.063 (n = 12).
Brachial artery pulse arrival intervals (QKd) decreased from 224 ± 10 to 200 ± 13 msec (n = 10) and correlated significantly with serum TSH and T4 levels, but not T3.

Cite This Study

Ridgway et al. (1981) studied this question.

synapsesocial.com/papers/6a703a86e5469ee92be0fbd1 https://doi.org/10.1210/jcem-53-6-1238

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December 1, 1981The Journal of Clinical Endocrinology & MetabolismOpen Access

Peripheral Responses to Thyroid Hormone before and after L-Thyroxine Therapy in Patients with Subclinical Hypothyroidism*

View Full Paper

Ask AI

Bookmark

Authors

ERE. Chester Ridgway DCDavid S. Cooper HWHarriet Walker

Discussion

Member takes

Overview

Interventional study reveals improved cardiac systolic time intervals with levothyroxine in subclinical hypothyroidism, indicating tissue-level hormone deficiency.

Key Points

To evaluate whether patients with subclinical hypothyroidism have peripheral cardiac abnormalities that normalize following L-thyroxine replacement therapy.
Assessed 20 patients presenting with elevated serum TSH levels but normal serum T4 and T3 concentrations before and after treatment with L-thyroxine.
Measured circulating thyroid hormone concentrations alongside noninvasive cardiac systolic time intervals, including preejection period and arterial pulse arrival time (QKd).
L-thyroxine therapy increased serum T4 from 5.5 ± 1.1 to 8.8 ± 1.8 µg/dl and serum T3 from 116 ± 20 to 137 ± 28 ng/dl.
Cardiac systolic time intervals significantly decreased (P < 0.01), with the preejection period declining from 123 ± 18 to 114 ± 14 msec (n = 12) and the preejection period to left ventricular ejection time ratio decreasing from 0.412 ± 0.068 to 0.357 ± 0.063 (n = 12).
Brachial artery pulse arrival intervals (QKd) decreased from 224 ± 10 to 200 ± 13 msec (n = 10) and correlated significantly with serum TSH and T4 levels, but not T3.

Cite This Study

Ridgway et al. (1981) studied this question.

synapsesocial.com/papers/6a703a86e5469ee92be0fbd1 https://doi.org/10.1210/jcem-53-6-1238

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