Heart attack induced experimentally with thromboxane A2.

The intracoronary injection of TA2, in a dose of 0.06 to 1.3μg in terms of norepinephrine, induced in rabbits, in a dose dependent manner, mild to severe ischemic myocardial changes, i.e., an angina pectoris-like response, variant angina-like response, myocardial infarction and sudden cardiac death.