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January 13, 2003Journal of VirologyOpen Access

The Foot-and-Mouth Disease Virus cis -Acting Replication Element ( cre ) Can Be Complemented in trans within Infected Cells

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Population

Foot-and-mouth disease virus (FMDV) infected cells

Design

Preclinical

Authors

LTLaurence TileyAKAndrew M. Q. KingGBGraham J. Belsham

Discussion

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Overview

Supports renaming FMDV cre as 3B-uridylylation site; leaves open validation beyond this model.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) infected cells
I
Intervention
Temperature-sensitive (ts) mutation within the 5'-untranslated region destabilizing the cis-acting replication element (cre)
O
Outcome
Virus replication complementation in trans

The study demonstrates that the FMDV cis-acting replication element can function in trans, suggesting it should be renamed a 3B-uridylylation site.

Cite This Study

Tiley et al. (2003) studied this question.

synapsesocial.com/papers/6a703af08031ec7bb1dc33cehttps://doi.org/10.1128/jvi.77.3.2243-2246.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification and Characterization of a <i>cis</i> -Acting Replication Element ( <i>cre</i> ) Adjacent to the Internal Ribosome Entry Site of Foot-and-Mouth Disease Virus2002 · 164 citations
  2. 2Identification of a <i>cis</i> -Acting Replication Element within the Poliovirus Coding Region2000 · 249 citations
  3. 3Genetic and Biochemical Studies of Poliovirus <i>cis</i> -Acting Replication Element <i>cre</i> in Relation to VPg Uridylylation2000 · 169 citations
  4. 4Temperature-sensitive RNA polymerase mutants of a picornavirus.1981 · 21 citations
  5. 5The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication1998 · 173 citations