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September 3, 2002Journal of VirologyOpen Access

Identification and Characterization of a cis -Acting Replication Element ( cre ) Adjacent to the Internal Ribosome Entry Site of Foot-and-Mouth Disease Virus

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Population

Foot-and-mouth disease virus (FMDV) genomes and replicons

Comparison

Mutations in the cre and relocation of cre to… vs Wild-type FMDV genomes and replicons

Design

Preclinical

Authors

PMPeter W. MasonSBSvetlana V. BezborodovaTHTina M. Henry

Discussion

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Overview

Supports cre motif and stem requirements for FMDV replication; leaves open antiviral targeting and in vivo validation.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) genomes and replicons
I
Intervention
Mutations in the cre (AAACA motif and stem region) and relocation of cre to the 3' end
C
Comparator
Wild-type FMDV genomes and replicons
O
Outcome
Viral replication and IRES-mediated translation

The cis-acting replicative element (cre) in FMDV is essential for viral replication, requires a conserved AAACA motif and stem-loop structure, but its position within the genome is flexible.

Cite This Study

Mason et al. (2002) studied this question.

synapsesocial.com/papers/6a7d0d88166e996abdd59f2ehttps://doi.org/10.1128/jvi.76.19.9686-9694.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic and Biochemical Studies of Poliovirus <i>cis</i> -Acting Replication Element <i>cre</i> in Relation to VPg Uridylylation2000 · 169 citations
  2. 2The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication1998 · 173 citations
  3. 3A region of the 5' noncoding region of foot-and-mouth disease virus RNA directs efficient internal initiation of protein synthesis within cells: involvement with the role of L protease in translational control1990 · 182 citations
  4. 4Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Identification of a <i>cis</i> -Replicating Element in the Coding Sequence of 2A <sup>pro</sup>2001 · 103 citations
  5. 5A cell cycle-dependent protein serves as a template-specific translation initiation factor2000 · 299 citations