Population
Myosin-1a knockout mice
Design
Preclinical
Authors
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Cellular defects without overt phenotypes in myosin-1a knockouts warrant caution extrapolating to organism level; leaves open compensatory mechanisms in brush border maintenance.
Myosin-1a is critical for maintaining the normal composition and highly ordered structure of the enterocyte brush border.
Tyska et al. (2005) studied this question.
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