Population
Wild-type (WT) and Myo1a knockout (KO) mice brush borders
Comparison
Myo1a knockout vs Wild-type (WT) mice
Design
Preclinical
Authors
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Hypothesis-generating for Myo1d compensation in Myo1a KO; leaves open whether dynamics govern class I myosin localization in vivo.
Myo1d may be the primary compensating class I myosin in the Myo1a KO model, suggesting that dynamics govern the localization and function of closely related myosins.
Benesh et al. (2010) studied this question.
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