Why the study?
Does advancing age affect NOS, oxidative stress, and vascular function differently in male and female rats?
Does advancing age affect NOS, oxidative stress, and vascular function differently in male and female rats?
Vascular function is maintained in aged rats despite increased oxidative stress and sex-specific alterations in the NOS system, suggesting the involvement of multiple compensating vasoactive pathways.
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Supports investigation of compensatory vasoactive pathways in vascular aging; should not yet inform clinical practice in humans.
Sullivan et al. (2004) studied this question.
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