Why the study?
Does losartan or verapamil improve vascular reactivity and reduce tissue endothelin-1 levels in Ang II-induced hypertensive rats?
Population
Wistar-Kyoto rats treated for 2 weeks with Ang II (200 ng x kg(-1) x min(-1)) to induce hypertension
Comparison
Losartan or verapamil vs Ang II-treated rats without concomitant…
Design
Preclinical
Follow-up
2 weeks
Authors
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AT1 blockade may uniquely affect endothelin-1 in experimental hypertension; hypothesis-generating and leaves open human translation.
Does losartan or verapamil improve vascular reactivity and reduce tissue endothelin-1 levels in Ang II-induced hypertensive rats?
Losartan, but not verapamil, prevents the increase in tissue endothelin-1 content in Ang II-induced hypertension, suggesting a specific role for AT1 receptor antagonists in modulating endothelin-1 in vivo.
d’Uscio et al. (1998) studied this question.
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