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June 1, 1996AnesthesiologyOpen Access

Chlorocresol, an Additive to Commercial Succinylcholine, Induces Contracture of Human Malignant Hyperthermia-susceptible Muscles Via Activation of the Ryanodine Receptor Calcium sup 2+ Channel

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Population

Muscle biopsies from malignant hyperthermia-susceptible and -negative individuals, and isolated rabbit…

Design

Preclinical

Authors

VTVincenzo TegazzinAzienda Ospedaliera Universitaria SeneseESErica ScutariCentre National de la Recherche ScientifiqueSTSusan TrevesUniversity of Ferrara

Discussion

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Implication

Chlorocresol may contribute to MH risk with commercial succinylcholine; hypothesis-generating and should not yet alter practice.

Structured PICO

P
Population
Muscle biopsies from malignant hyperthermia-susceptible (MHS) and -negative (MHN) individuals, and isolated rabbit sarcoplasmic reticulum fractions
I
Intervention
Chlorocresol (20-50 microM)
O
Outcome
Muscle contracture and Ca2+ flux/releasesurrogate

Chlorocresol, a preservative in commercial succinylcholine, induces muscle contracture in malignant hyperthermia-susceptible individuals, suggesting the additive rather than the drug alone may trigger the response.

Cite This Study

Tegazzin et al. (1996) studied this question.

synapsesocial.com/papers/6a703dc2f44fa9f079ddd1f6https://doi.org/10.1097/00000542-199606000-00014
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1INTRACELLULAR CALCIUM HOMEOSTASIS1987 · 2,179 citations
  2. 2Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia1991 · 1,497 citations
  3. 3Drug-induced Ca2+ release from isolated sarcoplasmic reticulum. II. Releases involving a Ca2+-induced Ca2+ release channel.1987 · 139 citations