Why the study?
Is the CASQ1 gene associated with malignant hyperthermia susceptibility in the North American population?
Population
Unrelated individuals from the North American population, including 130 malignant hyperthermia susceptible…
Comparison
DNA sequencing and genotyping of the CASQ1 gene vs MH negative individuals and normal controls
Design
Case-control
Authors
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No CASQ1 association with MHS detected; leaves open identification of other susceptibility loci in North American cohorts.
Is the CASQ1 gene associated with malignant hyperthermia susceptibility in the North American population?
The CASQ1 gene is not a major locus for malignant hyperthermia susceptibility in the North American population.
Kraeva et al. (2013) studied this question.
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